Female (2,080); Male (2,250); Not Reported (503)

0 to 4 years (1,773); 5 to 9 years (926); 10 to 14 years (872); 15 to 19 years (596); 20 to 24 years (30); Pediatric and Young Adult (<40 years) (636)

American Indian or Alaska Native (2); Asian (5); Black or African American (686); Native Hawaiian or Other Pacific Islander (1); White (3,515); Not Reported (624)

Hispanic or Latino (132); Not Hispanic or Latino (4,156); Not Reported (544); Unknown (1)

Acinar Cell Carcinoma (1); Acute Leukemias of Ambiguous Lineage (1); Acute Lymphoblastic Leukemia, NOS (694); Acute Megakaryoblastic Leukemia (4); Acute Myeloid Leukemia (92); Acute Myeloid Leukemia, Core Binding Factor (26); Acute Myeloid Leukemia, KMT2A rearrangement (3); Acute Myelomonocytic Leukemia (2); Acute Promyelocytic Leukemia (11); Acute Promyelocytic Leukemia, PML-RARA (1); Adenocarcinoma, NOS (4); Adrenocortical Carcinoma (7); Alveolar Rhabdomyosarcoma (13); Alveolar Rhabdomyosarcoma; Rhabdomyosarcoma, NOS (1); Alveolar Soft Part Sarcoma (10); Anaplastic Large Cell Lymphoma (5); Angiomatoid Fibrous Histiocytoma (1); Astrocytoma, NOS (28); Atypical Meningioma (1); B-cell Acute Lymphoblastic Leukemia, BCR-ABL1 (3); B-cell Acute Lymphoblastic Leukemia, BCR-ABL1 like (7); B-cell Acute Lymphoblastic Leukemia, DUX4-IGH (9); B-cell Acute Lymphoblastic Leukemia, DUX4-IGH like (1); B-cell Acute Lymphoblastic Leukemia, ETV6-RUNX1 (27); B-cell Acute Lymphoblastic Leukemia, ETV6-RUNX1 like (3); B-cell Acute Lymphoblastic Leukemia, Hyperdiploidy (38); B-cell Acute Lymphoblastic Leukemia, Hypodiploidy (4); B-cell Acute Lymphoblastic Leukemia, iAMP21 (4); B-cell Acute Lymphoblastic Leukemia, KMT2A rearrangement (9); B-cell Acute Lymphoblastic Leukemia, MEF2D rearrangement (1); B-cell Acute Lymphoblastic Leukemia, NOS (356); B-cell Acute Lymphoblastic Leukemia, NUTM1 rearrangement (1); B-cell Acute Lymphoblastic Leukemia, PAX5 alteration (1); B-cell Acute Lymphoblastic Leukemia, TCF3-PBX1 (20); B-cell Acute Lymphoblastic Leukemia, TCF3-PBX1; High-Grade Glioma, NOS (1); B-cell Acute Lymphoblastic Leukemia, ZNF384 rearrangement (1); Basal Cell Carcinoma (1); Botryoid Type Embryonal Rhabdomyosarcoma (3); Burkitt Lymphoma (54); Carcinoma, NOS (3); Central Neurocytoma (2); Chondroblastic Osteosarcoma (2); Chondrosarcoma (3); Choriocarcinoma (2); Choroid Plexus Carcinoma (4); Chronic Myeloid Leukemia (2); Clear Cell Sarcoma of Kidney (2); Congenital Mesoblastic Nephroma (5); Control Sample (447); Craniopharyngioma, NOS (22); Dermatofibrosarcoma Protuberans (4); Desmoid/Aggressive Fibromatosis (1); Desmoplastic Small Round Cell Tumor (1); Desmoplastic/Nodular Medulloblastoma (6); Diffuse Large B-cell Lymphoma, NOS (54); Dysembryoplastic Neuroepithelial Tumor (2); Dysgerminoma (9); Embryonal Carcinoma, NOS (7); Embryonal Rhabdomyosarcoma (59); Embryonal Rhabdomyosarcoma; Osteosarcoma; Therapy-Related Myeloid Neoplasm (1); Endometrioid Adenocarcinoma, NOS (1); Ependymomal Tumor (49); Ependymomal Tumor, Posterior Fossa (11); Ependymomal Tumor, Supratentorial (3); Epithelioid Hemangioendothelioma (2); Epithelioid Sarcoma (5); Ewing Sarcoma (96); Ewing Sarcoma; Hodgkin Lymphoma (1); Fibrillary Astrocytoma (3); Fibroblastic Osteosarcoma (1); Fibrosarcoma, NOS (4); Follicular Thyroid Cancer (1); Gangliocytoma (2); Ganglioglioma (3); Ganglioneuroblastoma (30); Ganglioneuroma (1); General Leukemia (3); Germ Cell Tumor, NOS (27); Germinoma (16); Giant Cell Tumor, NOS (3); Glioblastoma (1); Glioma, NOS (2); Granulosa Cell Tumor (3); Hepatoblastoma (16); Hepatocellular Carcinoma (8); High-Grade Glioma, NOS (37); Hodgkin Lymphoma (131); Infantile Fibrosarcoma (4); Langerhans Cell Histiocytosis (32); Leiomyosarcoma, NOS (2); Liposarcoma (3); Liver Malignancy, NOS (2); Low-Grade Glioma, NOS (39); Lymphocyte-Depleted Classical Hodgkin Lymphoma (4); Lymphocyte-Rich Classical Hodgkin Lymphoma (26); Malignant Fibrous Histiocytoma (7); Malignant Mesenchymoma (3); Malignant Mesenchymoma of the Liver (1); Malignant Peripheral Nerve Sheath Tumor (8); Medulloblastoma (130); Medulloblastoma, Group 3 (3); Medulloblastoma, Group 4 (6); Medulloblastoma, SHH subtype (2); Medulloblastoma, WNT subtype (4); Medulloepithelioma (1); Melanoma (40); Mesenchymal Chondrosarcoma (1); Miscellaneous Brain Tumor (206); Mixed Cellularity Classical Hodgkin Lymphoma (79); Mixed Germ Cell Tumor, Brain (1); Mixed Germ Cell Tumor, NOS (3); Mucinous Adenocarcinoma of the Colon and Rectum (1); Mucinous Adenocarcinoma, NOS (2); Mucoepidermoid Carcinoma (2); Mycosis Fungoides (2); Myxopapillary Ependymoma (2); Nasopharyngeal Carcinoma (28); Neuroblastoma (185); Neuroepithelioma (21); Nodular Lymphocyte-Predominant Hodgkin Lymphoma (4); Nodular Sclerosis Classical Hodgkin Lymphoma (219); Non-Hodgkin Lymphoma (164); Non-Malignancy (11); Oligodendroglioma (10); Osteosarcoma (144); Papillary Ependymoma, NOS (1); Papillary Thyroid Cancer (1); Paraganglioma (2); Parosteal Osteosarcoma (3); Periosteal Osteosarcoma (1); Peripheral Primitive Neuroectodermal Tumor (2); Pilocytic Astrocytoma (46); Pineoblastoma (1); Pleomorphic Xanthoastrocytoma (3); Pleuropulmonary Blastoma (1); Primitive Neuroectodermal Tumor (1); Renal Cell Carcinoma (5); Retinoblastoma (259); Rhabdoid Cancer, Kidney (1); Rhabdomyosarcoma (70); Serous Surface Papillary Carcinoma (1); Small Cell Osteosarcoma (1); Soft Tissue Sarcoma, NOS (48); Solid Cancer of Unknown Primary (15); Solitary Fibrous Tumor/Hemangiopericytoma (3); Spindle Cell Rhabdomyosarcoma (3); Spindle Cell Sarcoma, NOS (1); Squamous Cell Carcinoma, NOS (1); Subependymal Giant Cell Astrocytoma (1); Synovial Sarcoma (17); T-cell Acute Lymphoblastic Leukemia, KMT2A rearrangement (1); T-cell Acute Lymphoblastic Leukemia, NOS (75); Telangiectatic Osteosarcoma (3); Teratocarcinoma (2); Teratoma, NOS (15); Wilms (269); Yolk Sac Tumor, NOS (21); Not Reported (10)

Not Reported (4,833)

Whole Exome Sequencing (13,304); Whole Genome Sequencing (19,352)